The Aflac All-American High School Baseball Classic is an annual all-star game showcasing the top 40 rising high school senior baseball players in the country. This East vs. West matchup is played the summer before the players' senior year in high school. Each year an MLB Hall of Famer is selected to serve as the Honorary Chairman. The Honorary Chairman works to raise awareness for the Game and its charitable cause towards the research and treatment of cancer. The Chairman also serves as a Role model to the selected Aflac All-Americans, sharing insight with the players about his MLB and life experiences.

The Game's alumni have experienced tremendous success in the June MLB draft, with 65 of 230 All-American players being drafted by MLB teams in the first round and 3 first overall (Matt Bush in 2004, Justin Upton in 2005 and Tim Beckham in 2008).